An essential aspect of creating a hand-look design is to create a sense of movement.
For that, we want to create random long and short satin stitches, as well as contoured runs to fill large open shapes. More importantly are the stitch properties. Decrease the density of satin stitches and open up the stitches with increased auto spacing. Remove underlay. Similarly, open up the outlines with a larger-than-normal run stitch length.
Finally, make sure to add stitch mass for that real hand-stitched look.